A truncating mutation of Alms1 reduces the number of hypothalamic neuronal cilia in obese mice.

@article{Heydet2013ATM,
  title={A truncating mutation of Alms1 reduces the number of hypothalamic neuronal cilia in obese mice.},
  author={D{\'e}borah Heydet and Lesley X Chen and Claire Z Larter and Chrystal D Inglis and Michael A Silverman and Geoffrey C. Farrell and Michel R Leroux},
  journal={Developmental neurobiology},
  year={2013},
  volume={73 1},
  pages={
          1-13
        }
}
Primary cilia are ubiquitous cellular antennae whose dysfunction collectively causes various disorders, including vision and hearing impairment, as well as renal, skeletal, and central nervous system anomalies. One ciliopathy, Alström syndrome, is closely related to Bardet-Biedl syndrome (BBS), sharing amongst other phenotypic features morbid obesity. As the cellular and molecular links between weight regulation and cilia are poorly understood, we used the obese mouse strain foz/foz, bearing a… CONTINUE READING
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