A truncated splice-variant of the FcεRIβ receptor subunit is critical for microtubule formation and degranulation in mast cells.

Abstract

Human linkage analyses have implicated the MS4A2-containing gene locus (encoding FcεRIβ) as a candidate for allergy susceptibility. We have identified a truncation of FcεRIβ (t-FcεRIβ) in humans that contains a putative calmodulin-binding domain and thus, we sought to identify the role of this variant in mast cell function. We determined that t-FcεRIβ is… (More)
DOI: 10.1016/j.immuni.2013.04.007

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@article{Cruse2013ATS, title={A truncated splice-variant of the FcεRIβ receptor subunit is critical for microtubule formation and degranulation in mast cells.}, author={Glenn Cruse and Michael A. Beaven and Ian Ashmole and Peter Bradding and Alasdair M. Gilfillan and Dean D Metcalfe}, journal={Immunity}, year={2013}, volume={38 5}, pages={906-17} }