A truncated herpes simplex virus thymidine kinase phosphorylates thymidine and nucleoside analogs and does not cause sterility in transgenic mice.

@article{Salomon1995ATH,
  title={A truncated herpes simplex virus thymidine kinase phosphorylates thymidine and nucleoside analogs and does not cause sterility in transgenic mice.},
  author={Beno{\^i}t L. Salomon and St{\'e}phane Maury and Laurence S. Loubi{\`e}re and Maurizia Caruso and Rosine Onclercq and David Klatzmann},
  journal={Molecular and cellular biology},
  year={1995},
  volume={15 10},
  pages={5322-8}
}
Dividing eukaryotic cells expressing the herpes simplex virus type 1 thymidine kinase (TK) gene are sensitive to the cytotoxic effect of nucleoside analogs such as acyclovir or ganciclovir (GCV). Transgenic mice with cell-targeted expression of this conditional toxin have been used to create animals with temporally controlled cell-specific ablation. In these animal models, which allow the study of the physiological importance of a cell type, males are sterile. In this study, we showed that this… CONTINUE READING

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