A truncated fragment of Src protein kinase generated by calpain-mediated cleavage is a mediator of neuronal death in excitotoxicity.

Abstract

Excitotoxicity resulting from overstimulation of glutamate receptors is a major cause of neuronal death in cerebral ischemic stroke. The overstimulated ionotropic glutamate receptors exert their neurotoxic effects in part by overactivation of calpains, which induce neuronal death by catalyzing limited proteolysis of specific cellular proteins. Here, we… (More)
DOI: 10.1074/jbc.M112.419713

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Cite this paper

@article{Hossain2013ATF, title={A truncated fragment of Src protein kinase generated by calpain-mediated cleavage is a mediator of neuronal death in excitotoxicity.}, author={Md. Iqbal Hossain and Carli Lorraine Roulston and Mohd Aizuddin Kamaruddin and Percy W Y Chu and Dominic C. H. Ng and Gregory James Dusting and Jeffrey D Bjorge and Nicholas Williamson and Donald J. Fujita and Steve N Cheung and Tung O. Chan and Andrew F. Hill and Heung-Chin Cheng}, journal={The Journal of biological chemistry}, year={2013}, volume={288 14}, pages={9696-709} }