A truncated form of RGS3 negatively regulates G protein-coupled receptor stimulation of adenylyl cyclase and phosphoinositide phospholipase C.

@article{Chatterjee1997ATF,
  title={A truncated form of RGS3 negatively regulates G protein-coupled receptor stimulation of adenylyl cyclase and phosphoinositide phospholipase C.},
  author={Tapan Kumar Chatterjee and Alex K Eapen and Rory A Fisher},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 24},
  pages={15481-7}
}
Identification of a new family of proteins (RGS proteins) that function as negative regulators of G protein signaling has sparked new understanding of desensitization of this signaling process. Recent studies with several mammalian RGS proteins has delineated their ability to interact with and function as GTPase-activating proteins specifically for G proteins in the Gi family. Here, we investigated the functional activity of RGS3 and a truncated form of RGS3 on G protein-coupled receptor… CONTINUE READING

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