A truncated analogue of CCL2 mediates anti-fibrotic effects on murine fibroblasts independently of CCR2.


The truncated [1+9-76] CCL2 analogue, also known as 7ND, has been described in numerous reports as an anti-inflammatory and anti-fibrotic agent in a wide spectrum of animal models, e.g. models of cardiovascular disease, graft versus host disease and bleomycin-induced pulmonary fibrosis. 7ND has been reported to function as a competitive inhibitor of CCL2… (More)
DOI: 10.1016/j.bcp.2011.12.001