A true threshold dose in chemical carcinogenesis cannot be defined for a population, irrespective of the mode of action.

@article{Lutz2000ATT,
  title={A true threshold dose in chemical carcinogenesis cannot be defined for a population, irrespective of the mode of action.},
  author={Werner K. Lutz},
  journal={Human & experimental toxicology},
  year={2000},
  volume={19 10},
  pages={566-8; discussion 571-2}
}
Strongly sigmoidal (S-shaped) dose-cancer incidence relationships are often observed in animal bioassays for carcinogenicity. If a genotoxic contribution is not plausible, an epigenetic mode of carcinogen action is proposed and a thresholded low dose-response suggested. In a strict sense, a threshold implies a no-yes situation, i.e., no effect up to the threshold dose and an effect above the threshold dose. A convincing explanation of the discontinuity of the gradient of the dose-response curve… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

Chemical carcinogenesis.

Anais da Academia Brasileira de Ciencias • 2007
View 6 Excerpts
Highly Influenced

Just who is at risk? The ethics of environmental regulation.

Human & experimental toxicology • 2011
View 2 Excerpts

Similar Papers

Loading similar papers…