A trivariate continual reassessment method for phase I/II trials of toxicity, efficacy, and surrogate efficacy.

Abstract

Recently, many Bayesian methods have been developed for dose finding when simultaneously modeling both toxicity and efficacy outcomes in a blended phase I/II fashion. A further challenge arises when all the true efficacy data cannot be obtained quickly after the treatment so that surrogate markers are instead used (e.g., in cancer trials). We propose a… (More)
DOI: 10.1002/sim.5477

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Cite this paper

@article{Zhong2012ATC, title={A trivariate continual reassessment method for phase I/II trials of toxicity, efficacy, and surrogate efficacy.}, author={Wei Zhong and Joseph S Koopmeiners and Bradley P. Carlin}, journal={Statistics in medicine}, year={2012}, volume={31 29}, pages={3885-95} }