A triterpene glycoside from black cohosh that inhibits osteoclastogenesis by modulating RANKL and TNFalpha signaling pathways.

@article{Qiu2007ATG,
  title={A triterpene glycoside from black cohosh that inhibits osteoclastogenesis by modulating RANKL and TNFalpha signaling pathways.},
  author={Samuel X Qiu and Chun Dan and L Ding and Shulin Peng and Shao-Nong Chen and N. R. Farnsworth and Jan A Nolta and Michael L Gross and Ping Zhou},
  journal={Chemistry & biology},
  year={2007},
  volume={14 7},
  pages={860-9}
}
Osteoporosis is a major age-related source of morbidity and mortality. Increased bone resorption mediated by osteoclasts is central to its pathogenesis. Cytokines, particularly RANKL and TNFalpha, are often increased under pathologic conditions, leading to enhanced osteoclastogenesis. Black cohosh (Actaea/Cimicifuga racemosa L), a popular herbal supplement for the treatment of menopausal symptoms, was recently shown to have the beneficial effect of preventing bone loss. Here, we demonstrate… CONTINUE READING

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