A triplet chemotherapy with cisplatin, docetaxel and gemcitabine in patients with advanced non-small-cell lung cancer: a phase I/II study

@article{Tabata2006ATC,
  title={A triplet chemotherapy with cisplatin, docetaxel and gemcitabine in patients with advanced non-small-cell lung cancer: a phase I/II study},
  author={Masahiro Tabata and Toshiyuki Kozuki and Hiroshi Ueoka and Katsuyuki Kiura and Shingo Harita and Atsuhiko Tada and Takuo Shibayama and Nagio Takigawa and Toshiro Yonei and Kenichi Gemba and Yoshihiko Segawa and Daizo Kishino and Shinya Tada and Shunkichi Hiraki and Mitsune Tanimoto},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2006},
  volume={60},
  pages={53-59}
}
We conducted a phase I/II study of triplet chemotherapy consisting of cisplatin (CDDP), docetaxel (DCT) and gemcitabine (GEM) in patients with advanced non-small-cell lung cancer (NSCLC). Fifty-three untreated patients with stage IIIB or IV NSCLC were enrolled. All drugs were given on days 1 and 8. The doses of CDDP and DCT were fixed at 40 mg/m2 and 30 mg/m2, respectively. In the phase I portion, a dose escalation study of GEM with starting dose of 400 mg/m2 was conducted and primary objective… CONTINUE READING

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