A trip through my life with an immunological theme.

@article{Janeway2002ATT,
  title={A trip through my life with an immunological theme.},
  author={Charles A. Jr. Janeway},
  journal={Annual review of immunology},
  year={2002},
  volume={20},
  pages={
          1-28
        }
}
In this essay, I make four points about the operation of the immune system. First, thanks to the innate immune system's regulation of the main costimulatory molecules CD80 and CD86, the immune system rarely mistakes a pathogen for a self-antigen. Second, the adaptive immune system consisting of T lymphocytes and B lymphocytes can mistake self for non-self because adaptive immunity is selected in single somatic cells. Third, the adaptive immune system of T lymphocytes and B lymphocytes is always… CONTINUE READING
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