A trio family study showing association of the lymphotoxin-α N26 (804A) allele with coronary artery disease

@article{Consortium2004ATF,
  title={A trio family study showing association of the lymphotoxin-$\alpha$ N26 (804A) allele with coronary artery disease},
  author={The Procardis Consortium},
  journal={European Journal of Human Genetics},
  year={2004},
  volume={12},
  pages={770-774}
}
Family-based studies to map susceptibility genes through linkage disequilibrium have been successful in early-onset diseases where parental-proband trios are readily collected, but are believed to be unworkable for late-onset diseases such as coronary artery disease (CAD). PROCARDIS is a European multicentre study that was designed to identify susceptibility genes for CAD. We have tested the transmission of a putatively functional allele, lymphotoxin-α N26 (804A), in more than 400 PROCARDIS… 

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