A tricistronic retroviral vector expressing natural antiangiogenic factors inhibits angiogenesis in vitro, but is not able to block tumor progression in vivo

@article{Ciafr2002ATR,
  title={A tricistronic retroviral vector expressing natural antiangiogenic factors inhibits angiogenesis in vitro, but is not able to block tumor progression in vivo},
  author={S A Ciafr{\`e} and Giovanni Barillari and Lucilla Bongiorno-Borbone and Francesca Wannenes and M. Izquierdo and M J Farace},
  journal={Gene Therapy},
  year={2002},
  volume={9},
  pages={297-302}
}
Angiogenesis, the formation of new blood vessels out of pre-existing capillaries, is essential for tumor progression. Many factors have been identified that are able to inhibit angiogenesis. Here, we report the construction of a tricistronic retroviral vector encoding two inhibitors of angiogenesis expressed in mammals: the N-terminal fragment of rat prolactin (16KrPRL) and a secreted form of human platelet factor 4 (sPF4). When transduced by this retroviral vector, a rat glioblastoma cell line… CONTINUE READING

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