A tribute to Sidney Farber – the father of modern chemotherapy

@article{Miller2006ATT,
  title={A tribute to Sidney Farber – the father of modern chemotherapy},
  author={Denis R. Miller},
  journal={British Journal of Haematology},
  year={2006},
  volume={134}
}
  • Denis R. Miller
  • Published 1 July 2006
  • Medicine, Biology
  • British Journal of Haematology
Sidney Farber, world‐renowned paediatric pathologist, made major contributions to his field but is acknowledged as the father of the modern era of chemotherapy. He recognised that folic acid stimulated leukaemic cell growth and enhanced disease progression. He hypothesised that folic acid antagonists would inhibit or arrest the proliferation of cancer cells. His landmark study, published in 1948, demonstrated that a number of folic acid antagonists, including 4‐aminopteroyl‐glutamic acid… 

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