A triazolam/amphetamine dose–effect interaction study: dissociation of effects on memory versus arousal

@article{Mintzer2007ATD,
  title={A triazolam/amphetamine dose–effect interaction study: dissociation of effects on memory versus arousal},
  author={Miriam Z. Mintzer and Roland R Griffiths},
  journal={Psychopharmacology},
  year={2007},
  volume={192},
  pages={425-440}
}
RationaleIn addition to producing robust memory impairment, benzodiazepines also induce marked sedation. Thus, it is possible that the observed amnestic effects are secondary to more global sedative effects and do not reflect a specific primary benzodiazepine effect on memory mechanisms.ObjectiveThe objective was to use the nonspecific stimulant d-amphetamine to dissociate the sedative and memory-impairing effects of the benzodiazepine triazolam.Materials and methodsSingle oral doses of placebo… CONTINUE READING

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