A triazine compound S06 inhibits proinvasive crosstalk between carcinoma cells and stromal fibroblasts via binding to heat shock protein 90.

@article{Jung2011ATC,
  title={A triazine compound S06 inhibits proinvasive crosstalk between carcinoma cells and stromal fibroblasts via binding to heat shock protein 90.},
  author={Da-Woon Jung and Jinmi Kim and Zhong Min Che and Eun-Sang Oh and Gicheon Kim and Soo Hyun Eom and Sin-Hyeog Im and Hyung-Ho Ha and Y. -S. Chang and Darren Reece Williams and Jin Oak Kim},
  journal={Chemistry & biology},
  year={2011},
  volume={18 12},
  pages={1581-90}
}
Carcinoma-associated fibroblasts (CAFs) promote tumor invasion by secreting soluble factors. A tagged triazine library was screened in our novel transwell coculture model of CAF and oral squamous cell carcinoma (OSCC). We discovered compound S06, which reduced OSCC invasion by inhibiting secretion of CAF-derived proinvasive chemokines. The N-terminus of Hsp90 was found to be the cellular target of S06. Importantly, S06 did not induce hepatic toxicity, a side effect associated with well-known… CONTINUE READING