A trial of topical acyclovir in genital herpes simplex virus infections.

  title={A trial of topical acyclovir in genital herpes simplex virus infections.},
  author={Lawrence Corey and Andre Joseph Nahmias and M E Guinan and Jacqueline Benedetti and Cathy W. Critchlow and King K. Holmes},
  journal={The New England journal of medicine},
  volume={306 22},
Seventy-seven patients with first episodes of genital herpes and 111 with recurrent episodes were enrolled in a double-blind trial comparing topical acyclovir with a placebo (polyethylene glycol ointment). Among acyclovir-treated patients with first-episode primary genital herpes, the mean duration of viral shedding (4.1 days) and the time to complete crusting of lesions present at the initiation of therapy (7.1 days) were shorter than among placebo recipients (7.0 and 10.5 days, respectively… CONTINUE READING

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