A transverse tubule NADPH oxidase activity stimulates calcium release from isolated triads via ryanodine receptor type 1 S -glutathionylation.

@article{Hidalgo2006ATT,
  title={A transverse tubule NADPH oxidase activity stimulates calcium release from isolated triads via ryanodine receptor type 1 S -glutathionylation.},
  author={Cecilia Hidalgo and Gina L S{\'a}nchez and Genaro C Barrientos and Paula Aracena-Parks},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 36},
  pages={26473-82}
}
We report here the presence of an NADPH oxidase (NOX) activity both in intact and in isolated transverse tubules and in triads isolated from mammalian skeletal muscle, as established by immunochemical, enzymatic, and pharmacological criteria. Immunohistochemical determinations with NOX antibodies showed that the gp91(phox) membrane subunit and the cytoplasmic regulatory p47(phox) subunit co-localized in transverse tubules of adult mice fibers with the alpha1s subunit of dihydropyridine… CONTINUE READING
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