A transposon-based genetic screen in mice identifies genes altered in colorectal cancer.

@article{Starr2009ATG,
  title={A transposon-based genetic screen in mice identifies genes altered in colorectal cancer.},
  author={Timothy K. Starr and Raha Allaei and Kevin A. T. Silverstein and Rodney A. Staggs and Aaron L. Sarver and Tracy L. Bergemann and Mihir Gupta and M Gerard O'Sullivan and Ilze Matise and Adam J. Dupuy and Lara S. Collier and Scott Powers and Ann L. Oberg and Yan W. Asmann and Stephen N. Thibodeau and Lino Tessarollo and Neal G. Copeland and Nancy A. Jenkins and Robert T. Cormier and David A. Largaespada},
  journal={Science},
  year={2009},
  volume={323 5922},
  pages={1747-50}
}
Human colorectal cancers (CRCs) display a large number of genetic and epigenetic alterations, some of which are causally involved in tumorigenesis (drivers) and others that have little functional impact (passengers). To help distinguish between these two classes of alterations, we used a transposon-based genetic screen in mice to identify candidate genes for CRC. Mice harboring mutagenic Sleeping Beauty (SB) transposons were crossed with mice expressing SB transposase in gastrointestinal tract… CONTINUE READING
Highly Influential
This paper has highly influenced 11 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS