A transposon-based analysis of gene mutations related to skin cancer development.

@article{Quintana2013ATA,
  title={A transposon-based analysis of gene mutations related to skin cancer development.},
  author={Rita M Quintana and Adam J. Dupuy and Ana Luisa Bravo and M. Llanos Casanova and Josefa P. Alameda and Angustias Page and Miguel S{\'a}nchez-Viera and {\'A}ngel Ram{\'i}rez and Manuel Navarro},
  journal={The Journal of investigative dermatology},
  year={2013},
  volume={133 1},
  pages={239-48}
}
Nonmelanoma skin cancer (NMSC) is by far the most frequent type of cancer in humans. NMSC includes several types of malignancies with different clinical outcomes, the most frequent being basal and squamous cell carcinomas. We have used the Sleeping Beauty transposon/transposase system to identify somatic mutations associated with NMSC. Transgenic mice bearing multiple copies of a mutagenic Sleeping Beauty transposon T2Onc2 and expressing the SB11 transposase under the transcriptional control of… CONTINUE READING

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