A transporter in the endoplasmic reticulum of Schizosaccharomyces pombe cells mediates zinc storage and differentially affects transition metal tolerance.

@article{Clemens2002ATI,
  title={A transporter in the endoplasmic reticulum of Schizosaccharomyces pombe cells mediates zinc storage and differentially affects transition metal tolerance.},
  author={Stephan Clemens and Tanja Bloss and Christoph Vess and Dieter Neumann and Dietrich H Nies and Uta Zur Nieden},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 20},
  pages={18215-21}
}
The cation diffusion facilitator (CDF) family represents a class of ubiquitous metal transporters. Inactivation of a CDF in Schizosaccharomyces pombe, Zhf, causes drastically different effects on the tolerance toward various metals. A deletion mutant is Zn(2+)/Co(2+)-hypersensitive yet displays significantly enhanced Cd(2+) and Ni(2+) tolerance. Accumulation of zinc, cobalt, and cadmium is reduced in mutant cells. Non-vacuolar zinc content, as measured by analytical electron microscopy, is… CONTINUE READING

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