A transmembrane serine residue in the Rot1 protein is essential for yeast cell viability.

@article{MartnezGaray2014ATS,
  title={A transmembrane serine residue in the Rot1 protein is essential for yeast cell viability.},
  author={Carlos Andr{\'e}s Mart{\'i}nez-Garay and Maria Angeles Juanes and J Carlos Igual and Ismael Mingarro and M Carmen Ba{\~n}{\'o}},
  journal={The Biochemical journal},
  year={2014},
  volume={458 2},
  pages={239-49}
}
Polar residues are present in TM (transmembrane) helices and may influence the folding or association of membrane proteins. In the present study, we use an in vivo approach to analyse the functional and structural roles for amino acids in membrane-spanning motifs using the Rot1 (reversal of Tor2 lethality 1) protein as a model. Rot1 is an essential membrane protein in Saccharomyces cerevisiae and it contains a single TM domain. An alanine insertion scanning analysis of this TM helix revealed… CONTINUE READING

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