A transmembrane residue influences the interaction of propofol with the strychnine-sensitive glycine alpha1 and alpha1beta receptor.

@article{Ahrens2008ATR,
  title={A transmembrane residue influences the interaction of propofol with the strychnine-sensitive glycine alpha1 and alpha1beta receptor.},
  author={J{\"o}rg Ahrens and Martin Leuwer and Sina Stachura and Klaus Krampfl and Delia Belelli and J J Lambert and Gertrud Haeseler},
  journal={Anesthesia and analgesia},
  year={2008},
  volume={107 6},
  pages={1875-83}
}
BACKGROUND Propofol, well known for its anesthetic effects, acts as a positive allosteric modulator of the alpha-aminobutyric acid type A (GABA(A)) receptor but also enhances the function of the glycine receptor. The GABA modulatory effects of propofol are influenced by an amino acid residue located within the second transmembrane domain (TM2) of the GABA(A) receptor beta subunit. In glycine alpha(1) subunits, the homologous residue (serine 267) affects the glycine modulatory actions of… CONTINUE READING

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