A translational study of the effects of ketamine and pregabalin on temporal summation of experimental pain.

@article{ArendtNielsen2011ATS,
  title={A translational study of the effects of ketamine and pregabalin on temporal summation of experimental pain.},
  author={Lars Arendt-Nielsen and Heikki Mansikka and Camilla Staahl and Huw Rees and Keith KC Tan and Trevor S. Smart and Russell Monhemius and Rie Suzuki and Asbj\orn Mohr Drewes},
  journal={Regional anesthesia and pain medicine},
  year={2011},
  volume={36 6},
  pages={585-91}
}
BACKGROUND AND OBJECTIVES Central sensitization is often seen in chronic pain. A relevant and potent mechanism of central sensitization is the central integration of nociceptive impulses. Temporal summation in humans and the wind-up process in animals share common features of central integration. This preclinical and clinical translational study… CONTINUE READING