A transitional extracellular matrix instructs cell behavior during muscle regeneration.

@article{Calve2010ATE,
  title={A transitional extracellular matrix instructs cell behavior during muscle regeneration.},
  author={Sarah Calve and Shannon Odelberg and Hans-Georg Simon},
  journal={Developmental biology},
  year={2010},
  volume={344 1},
  pages={259-71}
}
Urodele amphibians regenerate appendages through the recruitment of progenitor cells into a blastema that rebuilds the lost tissue. Blastemal formation is accompanied by extensive remodeling of the extracellular matrix. Although this remodeling process is important for appendage regeneration, it is not known whether the remodeled matrix directly influences the generation and behavior of blastemal progenitor cells. By integrating in vivo 3-dimensional spatiotemporal matrix maps with in vitro… CONTINUE READING
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Regeneration of a limb muscle in axolotl from minced fragments

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