A transit-amplifying population underpins the efficient regenerative capacity of the testis

@inproceedings{Carrieri2017ATP,
  title={A transit-amplifying population underpins the efficient regenerative capacity of the testis},
  author={Claudia Carrieri and Stefano Comazzetto and Amit Grover and Marcos Morgan and Andreas Buness and Claus Nerlov and D{\`o}nal O' Carroll},
  booktitle={The Journal of experimental medicine},
  year={2017}
}
The spermatogonial stem cell (SSC) that supports spermatogenesis throughout adult life resides within the GFRα1-expressing A type undifferentiated spermatogonia. The decision to commit to spermatogenic differentiation coincides with the loss of GFRα1 and reciprocal gain of Ngn3 (Neurog3) expression. Through the analysis of the piRNA factor Miwi2 (Piwil4), we identify a novel population of Ngn3-expressing spermatogonia that are essential for efficient testicular regeneration after injury… CONTINUE READING
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