A transient treatment of hippocampal neurons with alpha-tocopherol induces a long-lasting protection against oxidative damage via a genomic action.

@article{Ferreira2005ATT,
  title={A transient treatment of hippocampal neurons with alpha-tocopherol induces a long-lasting protection against oxidative damage via a genomic action.},
  author={Marie C{\'e}leste de Jesus Ferreira and Nadine Crouzin and G{\'e}rard Barbanel and Catherine Cohen-Solal and Max R{\'e}casens and Michel Vignes and Janique Guiramand},
  journal={Free radical biology & medicine},
  year={2005},
  volume={39 8},
  pages={1009-20}
}
Neuroprotection exerted by alpha-tocopherol against oxidative stress was investigated in cultured rat hippocampal neurons. In addition to its direct action as a radical scavenger revealed at concentrations above 10 microM, a transient application of 1 microM alpha-tocopherol phosphate (alpha-TP) to neurons induced a complete delayed long-lasting protection against oxidative insult elicited by exposure to Fe2+ ions, but not against excitotoxicity. A minimal 16-h application of alpha-TP was… CONTINUE READING

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