A transient receptor potential-like channel mediates synaptic transmission in rod bipolar cells.

@article{Zhou2009ATR,
  title={A transient receptor potential-like channel mediates synaptic transmission in rod bipolar cells.},
  author={Hongbo Zhou and J Alexander Heimel and Maarten Kamermans and Neal S Peachey and Ronald G Gregg and Scott Nawy},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2009},
  volume={29 19},
  pages={
          6088-93
        }
}
On bipolar cells are connected to photoreceptors via a sign-inverting synapse. At this synapse, glutamate binds to a metabotropic receptor which couples to the closure of a cation-selective transduction channel. The molecular identity of both the receptor and the G protein are known, but the identity of the transduction channel has remained elusive. Here, we show that the transduction channel in mouse rod bipolar cells, a subtype of On bipolar cell, is likely to be a member of the TRP family of… CONTINUE READING

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