A transient receptor potential channel expressed in taste receptor cells

@article{Prez2002ATR,
  title={A transient receptor potential channel expressed in taste receptor cells},
  author={C. A. P{\'e}rez and Liquan Huang and M. Rong and J. A. Kozak and A. Preuss and Hailin Zhang and M. Max and R. Margolskee},
  journal={Nature Neuroscience},
  year={2002},
  volume={5},
  pages={1169-1176}
}
We used differential screening of cDNAs from individual taste receptor cells to identify candidate taste transduction elements in mice. Among the differentially expressed clones, one encoded Trpm5, a member of the mammalian family of transient receptor potential (TRP) channels. We found Trpm5 to be expressed in a restricted manner, with particularly high levels in taste tissue. In taste cells, Trpm5 was coexpressed with taste-signaling molecules such as α-gustducin, Gγ13, phospholipase C-β2… Expand
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