A transient, EMT-linked loss of basement membranes indicates metastasis and poor survival in colorectal cancer.

@article{Spaderna2006ATE,
  title={A transient, EMT-linked loss of basement membranes indicates metastasis and poor survival in colorectal cancer.},
  author={Simone Spaderna and Otto Schmalhofer and Falk Hlubek and Geert Berx and Andreas Eger and Susanne Merkel and Andreas Jung and Thomas W. Kirchner and T. Brabletz},
  journal={Gastroenterology},
  year={2006},
  volume={131 3},
  pages={830-40}
}
BACKGROUND & AIMS Loss of the basement membrane (BM) is considered an important step toward tumor malignancy. However, the BM is still expressed in most typical colorectal adenocarcinomas; nevertheless, these tumors can invade and develop metastases. The aim of this study was to investigate the role, mechanisms, and clinical relevance of BM turnover in malignant colorectal cancer (CRC) progression. METHODS Expression of BM components and their transcriptional regulation and clinical relevance… CONTINUE READING
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