A transient, EMT-linked loss of basement membranes indicates metastasis and poor survival in colorectal cancer.

Abstract

BACKGROUND & AIMS Loss of the basement membrane (BM) is considered an important step toward tumor malignancy. However, the BM is still expressed in most typical colorectal adenocarcinomas; nevertheless, these tumors can invade and develop metastases. The aim of this study was to investigate the role, mechanisms, and clinical relevance of BM turnover in… (More)

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@article{Spaderna2006ATE, title={A transient, EMT-linked loss of basement membranes indicates metastasis and poor survival in colorectal cancer.}, author={Simone Spaderna and Otto Schmalhofer and Falk Hlubek and Geert Berx and Andreas Eger and Susanne Merkel and Andreas Jung and Thomas Kirchner and Thomas Brabletz}, journal={Gastroenterology}, year={2006}, volume={131 3}, pages={830-40} }