A transgenic rat that develops Alzheimer's disease-like amyloid pathology, deficits in synaptic plasticity and cognitive impairment.

@article{Liu2008ATR,
  title={A transgenic rat that develops Alzheimer's disease-like amyloid pathology, deficits in synaptic plasticity and cognitive impairment.},
  author={Li Liu and Ian J Orozco and Emmanuel Planel and Yi ‐ Ying Wen and Alexis Bretteville and Pavan Krishnamurthy and Li-li Wang and Mathieu Herman and Helen Yvette Figueroa and Wai Haung Yu and Ottavio Arancio and Karen E Duff},
  journal={Neurobiology of disease},
  year={2008},
  volume={31 1},
  pages={46-57}
}
In the last decade, multiple lines of transgenic APP overexpressing mice have been created that recapitulate certain aspects of Alzheimer's disease (AD). However, none of the previously reported transgenic APP overexpressing rat models developed AD-like beta-amyloid (Abeta) deposits, or age-related learning and memory deficits. In the present study, we have characterized a transgenic rat model overexpressing transgenes with three, familial AD mutations (two in APP and one in PS1) that were… CONTINUE READING