A transgenic rat model of Alzheimer's disease with extracellular Abeta deposition.

@article{Flood2009ATR,
  title={A transgenic rat model of Alzheimer's disease with extracellular Abeta deposition.},
  author={Dorothy G. Flood and Yin-Guo Lin and Diane M Lang and Stephen P Trusko and James D Hirsch and Mary Josephine Savage and Richard W. Scott and David S Howland},
  journal={Neurobiology of aging},
  year={2009},
  volume={30 7},
  pages={1078-90}
}
Many transgenic mouse models of Alzheimer's disease (AD) that deposit amyloid (Abeta) have been produced, but development of an Abeta-depositing rat model has not been successful. Here, we describe a rat model with extracellular fibrillar Abeta deposition. Two lines of Sprague Dawley rats with transgenes expressing human amyloid precursor protein (APP) with the familial AD (FAD) mutations K670N/M671L and K670N/M671L/V717I were crossed. Abeta production in the double homozygous rats was… CONTINUE READING

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