A transgenic mouse model to inducibly target prosurvival Bcl2 proteins with selective BH3 peptides in vivo

Abstract

Dear Editor, BH3-mimetic drugs that antagonize Bcl-2 family prosurvival proteins are effective against some cancers, particularly those with abnormally high expression of the prosurvival protein target. Despite the recent success of BH3-mimetics targeting Bcl-2, Bcl-xL and Bcl-w, mechanism-based cell killing in vivo by targeting other important prosurvival… (More)
DOI: 10.1038/cddis.2015.54

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