A transgenic mouse model for mammary carcinogenesis

@article{Li1998ATM,
  title={A transgenic mouse model for mammary carcinogenesis},
  author={Baolin Li and Kristen L. Murphy and Rodolfo Laucirica and Frances S. Kittrell and Daniel J. Medina and Jeffrey M. Rosen},
  journal={Oncogene},
  year={1998},
  volume={16},
  pages={997-1007}
}
Missense mutations in the p53 tumor suppressor occur frequently in human breast cancer and influence both the prognosis and response to chemotherapy. Amino acid 175 (equivalent to murine 172) is the second most common site of missense mutations in p53 in human breast cancer. Over 95% of these mutations are arginine-to-histidine (R-H) substitutions resulting in a gain-of-function, and not merely a dominant-negative phenotype. Transgenic mice expressing a p53 172R–H construct targeted to the… CONTINUE READING
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