A transgenic mouse model for human neurofibromatosis.

  title={A transgenic mouse model for human neurofibromatosis.},
  author={Steven H. Hinrichs and M. A. H. Nerenberg and Roberta K. Reynolds and George Khoury and Gilbert Jay},
  volume={237 4820},
Human T-lymphotropic virus type 1 (HTLV-1) has been associated with the neurologic disorder tropical spastic paraparesis and possibly with multiple sclerosis. The tat gene of HTLV-1 under control of its own long terminal repeat is capable of inducing tumors in transgenic mice. The morphologic and biologic properties of these tumors indicate their close resemblance to human neurofibromatosis (von Recklinghausen's disease), the most common single gene disorder to affect the nervous system. The… CONTINUE READING