A transgenic model to determine the physiological role of liver-derived insulin-like growth factor I.

@article{Sjgren2002ATM,
  title={A transgenic model to determine the physiological role of liver-derived insulin-like growth factor I.},
  author={Klara Sj{\"o}gren and J O Jansson and Olle G. P. Isaksson and C Ohlsson},
  journal={Minerva endocrinologica},
  year={2002},
  volume={27 4},
  pages={299-311}
}
Insulin-like growth factor-I (IGF-I) has important growth promoting and metabolic effects and is expressed in virtually every tissue of the body. The highest expression is found in the liver but the physiological role of liver-derived IGF-I is unknown. It has been difficult to separate the endocrine effects of liver-derived IGF-I from the autocrine/paracrine effects of locally produced IGF-I in peripheral tissues. Therefore, we have developed a mouse model with a liver-specific inducible… CONTINUE READING

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