A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

@article{Carpten2007ATM,
  title={A transforming mutation in the pleckstrin homology domain of AKT1 in cancer},
  author={John D. Carpten and Andrew L. Faber and Candice L. Horn and Gregory P. Donoho and Stephen L. Briggs and Christiane M. Robbins and Galen H. Hostetter and Sophie Boguslawski and Tracy Y. Moses and Stephanie A Savage and Mark T Uhlik and Aimin Lin and Jian Du and Yue-wei Qian and Douglas J. Zeckner and Greg Tucker-Kellogg and Jeffrey W. Touchman and Ketan B. Patel and Spyro Mousses and Michael Bittner and Richard W. Schevitz and M T Lai and Kerry L. Blanchard and James E. Thomas},
  journal={Nature},
  year={2007},
  volume={448},
  pages={439-444}
}
Although AKT1 (v-akt murine thymoma viral oncogene homologue 1) kinase is a central member of possibly the most frequently activated proliferation and survival pathway in cancer, mutation of AKT1 has not been widely reported. Here we report the identification of a somatic mutation in human breast, colorectal and ovarian cancers that results in a glutamic acid to lysine substitution at amino acid 17 (E17K) in the lipid-binding pocket of AKT1. Lys 17 alters the electrostatic interactions of the… CONTINUE READING
Highly Influential
This paper has highly influenced 45 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 532 extracted citations

AKT signaling in ERBB2-amplified breast cancer.

Pharmacology & therapeutics • 2016
View 7 Excerpts
Highly Influenced

Activated PI3K/AKT and MAPK pathways are potential good prognostic markers in node-positive, triple-negative breast cancer.

Annals of oncology : official journal of the European Society for Medical Oncology • 2014
View 8 Excerpts
Highly Influenced

AKT1E17K in human solid tumours

Oncogene • 2008
View 6 Excerpts
Highly Influenced

Computational Identification of Significant Missense Mutations in AKT1 Gene

Cell Biochemistry and Biophysics • 2014
View 5 Excerpts
Highly Influenced

Gene alterations in the PI3K/PTEN/AKT pathway as a mechanism of drug-resistance (review).

International journal of oncology • 2012
View 5 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 36 references

Mutation of the PIK3CA gene in ovarian and breast cancer

Campbell, G I.
Cancer Res • 2004
View 6 Excerpts
Highly Influenced

The PIK3CA gene is mutated with high frequency in human breast cancers.

Cancer biology & therapy • 2004
View 7 Excerpts
Highly Influenced

The phosphatidylinositol 3-Kinase–AKT pathway in human cancer

Nature Reviews Cancer • 2002
View 6 Excerpts
Highly Influenced

Mutational analysis of AKT1, AKT2 and AKT3 genes in common human carcinomas

Soung, H Y.
Oncology 70, • 2006

Frequent mutation of the PIK3CA gene in ovarian and breast cancers.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2005

Identification and characterization of pleckstrin-homologydomain-dependent and isoenzyme-specific Akt inhibitors

Barnett, F S.
Biochem. J. 385, • 2005

Similar Papers

Loading similar papers…