A transendocytosis model of CTLA-4 function predicts its suppressive behavior on regulatory T cells.

@article{Hou2015ATM,
  title={A transendocytosis model of CTLA-4 function predicts its suppressive behavior on regulatory T cells.},
  author={Tie Zheng Hou and Omar S Qureshi and Chun Jing Wang and Jennifer H.E. Baker and Stephen P. Young and Lucy S K Walker and David M Sansom},
  journal={Journal of immunology},
  year={2015},
  volume={194 5},
  pages={
          2148-59
        }
}
Manipulation of the CD28/CTLA-4 pathway is at the heart of a number of immunomodulatory approaches used in both autoimmunity and cancer. Although it is clear that CTLA-4 is a critical regulator of T cell responses, the immunological contexts in which CTLA-4 controls immune responses are not well defined. In this study, we show that whereas CD80/CD86-dependent activation of resting human T cells caused extensive T cell proliferation and robust CTLA-4 expression, in this context CTLA-4 blocking… CONTINUE READING
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