A transcriptional serenAID: the role of noncoding RNAs in class switch recombination.

Abstract

During an immune response, activated B cells may undergo class switch recombination (CSR), a molecular rearrangement that allows B cells to switch from expressing IgM and IgD to a secondary antibody heavy chain isotype such as IgG, IgA or IgE. Secondary antibody isotypes provide the adaptive immune system with distinct effector functions to optimally combat… (More)
DOI: 10.1093/intimm/dxx027

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