A transcriptional response to replication status mediated by the conserved bacterial replication protein DnaA.

@article{Goranov2005ATR,
  title={A transcriptional response to replication status mediated by the conserved bacterial replication protein DnaA.},
  author={Alexi I. Goranov and Luba Katz and Adam M Breier and Christopher B. Burge and Alan D Grossman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 36},
  pages={12932-7}
}
Organisms respond to perturbations in DNA replication. We characterized the global transcriptional response to inhibition of DNA replication in Bacillus subtilis. We focused on changes that were independent of the known recA-dependent global DNA damage (SOS) response. We found that overlapping sets of genes are affected by perturbations in replication elongation or initiation and that this transcriptional response serves to inhibit cell division and maintain cell viability. Approximately 20 of… CONTINUE READING

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