A transcriptional repressor obtained by alternative translation of a trinucleotide repeat

@article{Lanz1995ATR,
  title={A transcriptional repressor obtained by alternative translation of a trinucleotide repeat},
  author={Rainer B. Lanz and Stefan Wieland and Martin Hug and Sandro Rusconi},
  journal={Nucleic acids research},
  year={1995},
  volume={23 1},
  pages={138-45}
}
Triplet nucleotide repeats are ubiquitous and rapidly evolving sequences in eucaryotic genomes. They are sporadically found in coding regions of transcription regulators where they become translated in different homopolymeric aminoacid (HPAA) stretches, depending on the local frame. Poly(CAG) yields three different HPAAs (poly Gln, Ser or Ala). Current sequence databases indicate a clear bias in the size and frequency of these HPAAs according to the rule: (Gln)n > (Ser)n >> (Ala)n. Aiming to… CONTINUE READING

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