A transcriptional co-repressor that interacts with nuclear hormone receptors

@article{Chen1995ATC,
  title={A transcriptional co-repressor that interacts with nuclear hormone receptors},
  author={J. Don Chen and Ronald M. Evans},
  journal={Nature},
  year={1995},
  volume={377},
  pages={454-457}
}
TRANSCRIPTIONAL silencing mediated by nuclear receptors is important in development, differentiation and oncogenesis1-3. The mechanism underlying this effect is unknown but is one key to understanding the molecular basis of hormone action. Here we identify a receptor-interacting factor, SMRT, as a silencing mediator (co-repressor) for retinoid and thyroid-hormone receptors. SMRT is a previously undiscovered protein whose association with receptors both in solution and bound to DNA-response… 
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