A transcription factor network represses CFTR gene expression in airway epithelial cells.

@article{Mutolo2018ATF,
  title={A transcription factor network represses CFTR gene expression in airway epithelial cells.},
  author={Michael J. Mutolo and Shih-Hsing Leir and Sara L. Fossum and James Alexander Browne and Ann Marie Harris},
  journal={The Biochemical journal},
  year={2018},
  volume={475 7},
  pages={1323-1334}
}
Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause the inherited disorder cystic fibrosis (CF). Lung disease is the major cause of CF morbidity, though CFTR expression levels are substantially lower in the airway epithelium than in pancreatic duct and intestinal epithelia, which also show compromised function in CF. Recently developed small molecule therapeutics for CF are highly successful for one specific CFTR mutation and have a positive impact on others… CONTINUE READING
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