A transcription factor interacting with the class I gene enhancer is inactive in tumorigenic cell lines which suppress major histocompatibility complex class I genes.

@article{Henseling1990ATF,
  title={A transcription factor interacting with the class I gene enhancer is inactive in tumorigenic cell lines which suppress major histocompatibility complex class I genes.},
  author={Ulf Henseling and Wilhelm Schmidt and Hans R. Sch{\"o}ler and P. Gruss and Antonis K. Hatzopoulos},
  journal={Molecular and cellular biology},
  year={1990},
  volume={10 8},
  pages={4100-9}
}
AKR leukemias display different amounts of major histocompatibility complex class I antigens on the cell surface. The absence of H-2Kk molecules correlates with the ability of these cell lines to form tumors in vivo as well as to escape lysis by cytotoxic T lymphocytes in vitro. In this report it is shown that the 5' regulatory area of the H-2Kk gene failed to activate transcription in H-2Kk-negative cells. Examination of the proteins interacting with the H-2Kk enhancer in expressing and… CONTINUE READING

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