A trans-receptor mechanism for infection of CD4-negative cells by human immunodeficiency virus type 1

@article{Speck1999ATM,
  title={A trans-receptor mechanism for infection of CD4-negative cells by human immunodeficiency virus type 1},
  author={Roberto F Speck and Ursula Esser and Michael L. Penn and Daniel A. Eckstein and Lynn Pulliam and Stephen Y. Chan and Mark Goldsmith},
  journal={Current Biology},
  year={1999},
  volume={9},
  pages={547-550}
}
Chemokine receptors, particularly CCR5 and CXCR4, act as essential coreceptors in concert with CD4 for cellular entry by human immunodeficiency virus type 1 (HIV-1; reviewed in [1]). But infection of CD4(-) cells has also been encountered in various tissues in vivo, including astrocytes, neurons and microvascular endothelial cells of the brain [2] [3] [4] [5] [6], epithelial cells [5] [7], CD4(-) lymphocytes and thymocytes [8] [9], and cardiomyocytes [10]. Here, we present evidence for the… CONTINUE READING