A trans-lentiviral packaging cell line for high-titer conditional self-inactivating HIV-1 vectors.

@article{Cockrell2006ATP,
  title={A trans-lentiviral packaging cell line for high-titer conditional self-inactivating HIV-1 vectors.},
  author={Adam S. Cockrell and Hong Ma and Kailing Fu and T. J. Mccown and Tal Kafri},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2006},
  volume={14 2},
  pages={
          276-84
        }
}
Lentiviral vector safety has been the impetus underlying the progress in packaging cell line development. The prospects of generating replication-competent lentiviruses (RCLs) and the potential for vector mobilization continue to be the driving force for the advancement of packaging cell lines. We have exploited the trans-lentiviral packaging system to develop the SODk3 packaging cell line for the generation of conditional self-inactivating (cSIN) vectors. Separating the gag-pol genome into two… CONTINUE READING

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