A trans-acting class II regulatory gene unlinked to the MHC controls expression of HLA class II genes

@article{Prval1985ATC,
  title={A trans-acting class II regulatory gene unlinked to the MHC controls expression of HLA class II genes},
  author={Claude de Pr{\'e}val and Barbara Lisowska-Grospierre and M P Loche and Claude Griscelli and Bernard Mach},
  journal={Nature},
  year={1985},
  volume={318},
  pages={291-293}
}
Class II (or Ia) antigens are highly polymorphic surface molecules which are essential for the cellular interactions involved in the immune response. In man, these antigens are encoded by a complex multigene family which is located in the major histocompatibility complex (MHC) and which comprises up to 12 distinct α- and β-chain genes, coding for the HLA-DR, -DQ and -DP antigens1,2. One form of congenital severe combined immunodeficiency (SCID) in man, which is generally lethal, is… CONTINUE READING

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