A toxicological and dermatological assessment of macrocyclic ketones when used as fragrance ingredients: the RIFM Expert Panel.

@article{Belsito2011ATA,
  title={A toxicological and dermatological assessment of macrocyclic ketones when used as fragrance ingredients: the RIFM Expert Panel.},
  author={Donald V. Belsito and David R. Bickers and Magnus Bruze and Peter Calow and M L Dagli and A D Fryer and Helmut Greim and Yoshimitsu Miyachi and Jean Hilaire Saurat and I. Glenn Sipes},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={2011},
  volume={49 Suppl 2},
  pages={
          S126-41
        }
}
  • D. Belsito, D. Bickers, +7 authors I. Sipes
  • Published 1 December 2011
  • Chemistry, Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
The macrocyclic ketone (MK) group of fragrance ingredients was evaluated for safety following a complete literature search. For high end users, calculated maximum dermal exposures vary from 0.13% to 1.10%; systemic exposures vary from 0.0005 to 0.0441 mg/kg/day. The MKs had low acute toxicity and no significant repeat dose toxicity. Liver weight and blood biochemistry effects were reversible after 2 weeks. No genotoxicity in bacteria and mammalian cell lines was observed. Reproductive toxicity… Expand
Fragrance material review on 3-methylcyclopentadecenone (mixed isomers).
  • D. Mcginty, C. Letizia, A. Api
  • Chemistry, Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2011
TLDR
A toxicologic and dermatologic review of 3-methylcyclopentadecenone when used as a fragrance ingredient is presented and a safety assessment of the entire macrocyclic ketones and derivatives will be published simultaneously with this document. Expand
Fragrance material review on cyclopentadecanone.
  • D. Mcginty, C. Letizia, A. Api
  • Chemistry, Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2011
TLDR
A toxicologic and dermatologic review of cyclopentadecanone when used as a fragrance ingredient is presented and a safety assessment of the entire macrocyclic ketone and derivatives will be published simultaneously with this document. Expand
Fragrance material review on cyclohexadecanone.
  • D. Mcginty, C. Letizia, A. Api
  • Chemistry, Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2011
TLDR
A toxicologic and dermatologic review of cyclohexadecanone when used as a fragrance ingredient is presented and includes: physical properties; acute toxicity; skin irritation; mucous membrane (eye) irritation; skin sensitization; repeated dose; and genotoxicity data. Expand
Fragrance material review on 3-methyl-1-cyclopentadecanone.
  • D. Mcginty, C. Letizia, A. Api
  • Chemistry, Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2011
TLDR
A toxicologic and dermatologic review of 3-methyl-1-cyclopentadecanone when used as a fragrance ingredient is presented and a safety assessment of the entire macrocyclic ketones and derivatives will be published simultaneously with this document. Expand
Fragrance material review on 3-phenylpropyl isobutyrate.
TLDR
A toxicologic and dermatologic review of 3-phenylpropyl isobutyrate when used as a fragrance ingredient is presented and includes physical properties, acute toxicity, skin irritation and skin sensitization. Expand
Fragrance material review on 3-phenyl-1-propanol.
TLDR
A toxicologic and dermatologic review of 3-phenyl-1-propanol when used as a fragrance ingredient is presented and includes physical properties, acute toxicity, skin irritation, skin sensitization, in vitro skin absorption and mutagenicity. Expand
Fragrance material review on 4-cyclopentadecen-1-one.
  • D. Mcginty, C. Letizia, A. Api
  • Chemistry, Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2011
TLDR
A toxicologic and dermatologic review of 4-cyclopentadecen-1-one when used as a fragrance ingredient is presented and a safety assessment of the entire macrocyclic ketones and derivatives will be published simultaneously with this document. Expand
Fragrance material review on 3-phenylpropyl cinnamate.
TLDR
A toxicologic and dermatologic review of 3-phenylpropyl cinnamate when used as a fragrance ingredient is presented and includes physical properties, acute toxicity, skin irritation and skin sensitization. Expand
Muscone Induces CYP1A2 and CYP3A4 Enzyme Expression in L02 Human Liver Cells and CYP1A2 and CYP3A11 Enzyme Expression in Kunming Mice
TLDR
The CYP-inductive effect that is caused by muscone encompasses a 6- to 12-day period of activity after drug administration as demonstrated by follow-up in vivo studies. Expand
Determination of synthetic musk fragrances
ABSTRACT Among personal care products (PCPs), musks fragrances are a chemically heterogeneous group sharing some sensory characteristics, specially related with odour aspects that have received greatExpand
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  • Chemistry, Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2011
TLDR
A toxicologic and dermatologic review of 3-methylcyclopentadecenone when used as a fragrance ingredient is presented and a safety assessment of the entire macrocyclic ketones and derivatives will be published simultaneously with this document. Expand
Fragrance material review on cyclopentadecanone.
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  • Chemistry, Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
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TLDR
A toxicologic and dermatologic review of cyclopentadecanone when used as a fragrance ingredient is presented and a safety assessment of the entire macrocyclic ketone and derivatives will be published simultaneously with this document. Expand
Fragrance material review on cyclohexadecanone.
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  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
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TLDR
A toxicologic and dermatologic review of cyclohexadecanone when used as a fragrance ingredient is presented and includes: physical properties; acute toxicity; skin irritation; mucous membrane (eye) irritation; skin sensitization; repeated dose; and genotoxicity data. Expand
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A toxicologic and dermatologic review of 3-methyl-1-cyclopentadecanone when used as a fragrance ingredient is presented and a safety assessment of the entire macrocyclic ketones and derivatives will be published simultaneously with this document. Expand
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  • Chemistry, Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2011
TLDR
A toxicologic and dermatologic review of 4-cyclopentadecen-1-one when used as a fragrance ingredient is presented and a safety assessment of the entire macrocyclic ketones and derivatives will be published simultaneously with this document. Expand
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