A toxicokinetic study of inhaled ethylene glycol ethyl ether acetate and validation of a physiologically based pharmacokinetic model for rat and human.

@article{Gargas2000ATS,
  title={A toxicokinetic study of inhaled ethylene glycol ethyl ether acetate and validation of a physiologically based pharmacokinetic model for rat and human.},
  author={Michael L. Gargas and Tom R. Tyler and Lisa M. Sweeney and Richard A. Corley and Karl K. Weitz and Terryl J Mast and Dennis J Paustenbach and Steve M Hays},
  journal={Toxicology and applied pharmacology},
  year={2000},
  volume={165 1},
  pages={63-73}
}
The solvents ethylene glycol monoethyl ether acetate (EGEEA) and ethylene glycol monoethyl ether (EGEE), at sufficiently high doses, are known to be rodent developmental toxicants, exerting their toxic effects through the action of their metabolite 2-ethoxyacetic acid (2-EAA). Thus risks associated with exposure to these compounds are best evaluated based… CONTINUE READING