A tour of structural genomics

@article{Brenner2001ATO,
  title={A tour of structural genomics},
  author={Steven E. Brenner},
  journal={Nature Reviews Genetics},
  year={2001},
  volume={2},
  pages={801-809}
}
  • S. Brenner
  • Published 1 October 2001
  • Biology, Chemistry
  • Nature Reviews Genetics
Structural genomics projects aim to provide an experimental or computational three-dimensional model structure for all of the tractable macromolecules that are encoded by complete genomes. To this end, pilot centres worldwide are now exploring the feasibility of large-scale structure determination. Their experimental structures and computational models are expected to yield insight into the molecular function and mechanism of thousands of proteins. The pervasiveness of this information is… 

Genome annotation and protein structure

  • S. Brenner
  • Biology
    Proceedings. IEEE Computer Society Bioinformatics Conference
  • 2002
This work has shown that knowledge of an increasingly complete repertoire of protein structures will aid structure prediction methods, improve understanding of protein structure, and ultimately lend insight into molecular interactions and pathways.

Computational Structural Genomics of a Complete Minimal Organism

Structural genomics aims to provide an experimental structure or computational model of every tractable protein in a complete genome, and is expected to yield important insight into the minimal set of genes necessary for life.

Understanding the molecular machinery of genetics through 3D structures

How changes in protein sequence affect the corresponding 3D structure is considered, and how structural information about proteins, DNA and chromatin has shed light on gene regulatory mechanisms and the storage and transmission of epigenetic information is described.

Focusing in on structural genomics: the University of Queensland structural biology pipeline.

Automatic target selection for structural genomics on eukaryotes

The results suggested that it might be necessary to determine >40,000 structures to minimally cover the subset of five eukaryotic proteomes, and it was suggested that all members of one family share a common foldlike region.

Exploiting protein structure data to explore the evolution of protein function and biological complexity

Structural analyses of metabolic families provide some insights into the mechanisms of functional innovation, which include changes in domain partnerships and significant structural embellishments leading to modulation of active sites and protein interactions.
...

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  • Biology, Chemistry
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