A tour of structural genomics

  title={A tour of structural genomics},
  author={Steven E. Brenner},
  journal={Nature Reviews Genetics},
  • S. Brenner
  • Published 1 October 2001
  • Biology, Chemistry
  • Nature Reviews Genetics
Structural genomics projects aim to provide an experimental or computational three-dimensional model structure for all of the tractable macromolecules that are encoded by complete genomes. To this end, pilot centres worldwide are now exploring the feasibility of large-scale structure determination. Their experimental structures and computational models are expected to yield insight into the molecular function and mechanism of thousands of proteins. The pervasiveness of this information is… 

Genome annotation and protein structure

  • S. Brenner
  • Biology
    Proceedings. IEEE Computer Society Bioinformatics Conference
  • 2002
This work has shown that knowledge of an increasingly complete repertoire of protein structures will aid structure prediction methods, improve understanding of protein structure, and ultimately lend insight into molecular interactions and pathways.

Computational Structural Genomics of a Complete Minimal Organism

Structural genomics aims to provide an experimental structure or computational model of every tractable protein in a complete genome, and is expected to yield important insight into the minimal set of genes necessary for life.

Understanding the molecular machinery of genetics through 3D structures

How changes in protein sequence affect the corresponding 3D structure is considered, and how structural information about proteins, DNA and chromatin has shed light on gene regulatory mechanisms and the storage and transmission of epigenetic information is described.

Focusing in on structural genomics: the University of Queensland structural biology pipeline.

Automatic target selection for structural genomics on eukaryotes

The results suggested that it might be necessary to determine >40,000 structures to minimally cover the subset of five eukaryotic proteomes, and it was suggested that all members of one family share a common foldlike region.

Exploiting protein structure data to explore the evolution of protein function and biological complexity

Structural analyses of metabolic families provide some insights into the mechanisms of functional innovation, which include changes in domain partnerships and significant structural embellishments leading to modulation of active sites and protein interactions.



Target selection for structural genomics

  • S. Brenner
  • Biology, Chemistry
    Nature Structural Biology
  • 2000
Structural genomics aims to use high-throughput structure determination and computational analysis to provide three-dimensional models of every tractable protein to be studied by crystallography or NMR.

Structural genomics: opportunities and challenges.

Expectations from structural genomics

It is expected that only about a quarter of the early structural genomics targets will have a new fold, and among the remaining ones, about half are likely to be evolutionarily related to proteins of known structure, even though the homology could not be readily detected by sequence analysis.

100,000 protein structures for the biologist

  • A. Sali
  • Biology
    Nature Structural Biology
  • 1998
Structural genomics promises to deliver experimentally determined three-dimensional structures for many thousands of protein domains so that the methods of fold assignment and comparative protein structure modeling will result in useful models for most other protein sequences.

Structural genomics and its importance for gene function analysis

This work has shown that assignment of a protein's biochemical function can be achieved by scanning its structure for a match to the geometry and chemical identity of a known active site and can use low-resolution structures provided by contemporary structure prediction methods.

An integrated approach to structural genomics.

Structural genomics projects in Japan.

Protein structure modeling for structural genomics

The shapes of most protein sequences will be modeled based on their similarity to experimentally determined protein structures, and the current role, limitations, challenges and prospects for protein structure modeling are discussed in the context of structural genomics.